Probing the Functional Conformation of Neuropeptide Y through the Design and Study of Cyclic Analogues

Article abstract of DOI:10.1021/jm00084a021

The functional importance of the PP-fold conformation in neuropeptide Y (NPY) was investigated.NPY and N^α-Ac-NPY(10-36), and corresponding cyclic analogues cyclo^18,22-18,Asp²²>-NPY and N^α-Ac-cyclo