Organic and Biomolecular Chemistry p. 6217 - 6229 (2012)
Update date:2022-08-04
Topics: Synthesis Stereochemistry Structure Enantiopure Bacterial metabolites Cyclohexenone
Boyd, Derek R.
Sharma, Narain D.
Malone, John F.
McIntyre, Peter B. A.
Stevenson, Paul J.
Allen, Christopher C. R.
Kwit, Marcin
Gawronski, Jacek
Biotransformation of 3-substituted and 2,5-disubstituted phenols, using whole cells of P. putida UV4, yielded cyclohexenone cis-diols as single enantiomers; their structures and absolute configurations have been determined by NMR and ECD spectroscopy, X-ray crystallography, and stereochemical correlation involving a four step chemoenzymatic synthesis from the corresponding cis-dihydrodiol metabolites. An active site model has been proposed, to account for the formation of enantiopure cyclohexenone cis-diols with opposite absolute configurations.
View MoreSuzhou SuKaiLu Chemical Technology Co., Ltd.
Contact:+86-512-62766020
Address:Floor 4, Building 1, Xinyi Pharmaceutical Valley Wisdom Industrial Park, 415 Changyang Street, Suzhou Industrial Park, Jiangsu Province
Tianjin Te-An Chemtech Co., Ltd.(expird)
Contact:+86-22-65378638
Address:A5-8, No.80 Haiyun Street, TEDA
Chemsigma International Co.,Ltd.
website:http://www.chemsigma.com
Contact:86-025-58748998
Address:Rm.705, 15th Building,Rd.Xinke II
Shanghai PengMo Biotechnology Co.,Ltd
website:http://www.pengmobio.lookchem.com
Contact:86-13052359378
Address:No.218 Hai Qu Road.Shanghai.China
Contact:+86-20-62802632;62802633
Address:Room 330 GIGCAS Building,No.511 Kehua Street,Tianhe District
Doi:10.1002/chem.201200992
(2012)Doi:10.1016/0040-4039(91)80453-D
(1991)Doi:10.1016/0223-5234(96)88220-1
(1995)Doi:10.1016/j.tet.2012.06.056
(2012)Doi:10.1039/c2cc32398b
(2012)Doi:10.1002/jhet.5570280836
(1992)
