Tetrahedron p. 7103 - 7115 (2012)
Update date:2022-08-03
Topics:
Sastraruji, Kwankamol
Sastraruji, Thanapat
Ung, Alison T.
Griffith, Renate
Jatisatienr, Araya
Pyne, Stephen G.
Thirty-two new stemofoline analogues were prepared from didehydrostemofoline for studies as AChE inhibitors. C-3 Side-chain modified amino, carbamate, triazole and oxazole stemofoline derivatives were prepared. In general the amine derivatives were found to be stronger inhibitors of AChE than their alcohol analogues that we previously reported. Compounds 5 and 26, with small C-3 side-chain substituents, were two of the most active inhibitors. Preliminary molecular docking studies suggested that these compounds may inhibit AChE by binding horizontally along the passage of the active-site gorge and block access to acetylcholine.
View Morewebsite:http://www.tcfinechem.com/
Contact:18681346930
Address:baifu town,whou district
Changzhou Welton Chemical Co., Ltd,
Contact:0086-519-85910828,85920537,85912897
Address:No.8 Jinlong Road, Binjiang Park, Changzhou, Jiangsu, China.
Chengdu CSH Pharmaceutical Co.,ltd
Contact:+86-(28)-85321971
Address:Block B,New Hope Int. Tian Fu New District, Chengdu, Sichuan, China
Rugao Jinling Chemical Co., Ltd.(expird)
Contact:0086-513-68005586
Address:Lianluo new village huangshi town Rugao city Jiangsu Province.
Shanghai Rainbow Chemistry Co., Ltd.
Contact:+86-21-64968086-5815/5812
Address:3rd floor, Building 7, 251 Faladi Road, Zhangjiang Hi-Tech Park, Pudong District, Shanghai, P.R. China
Doi:10.1002/(SICI)1099-0690(199912)1999:12<3421::AID-EJOC3421>3.0.CO;2-1
(1999)Doi:10.1016/j.bmcl.2012.05.117
(2012)Doi:10.1002/anie.201201541
(2012)Doi:10.1007/s12272-012-0704-8
(2012)Doi:10.1016/S0040-4039(01)90146-7
(1981)Doi:10.1007/BF00503339
(1981)