Chemical and Pharmaceutical Bulletin p. 2564 - 2573 (1991)
Update date:2022-08-05
Topics:
Kurokawa
Sato
Masuda
Yoshida
Ochi
Zushi
Fujiwara
Naruto
Uno
Matsumoto
A series of 11-[4-(cinnamyl)-1-piperazinyl]-6,11-dihydrodibenz[b,e]oxepins and related compounds were synthesized and evaluated for their protective activities against complete ischemia, normobaric hypoxia, lipidperoxidation and convulsion. Structure-activity relationship studies of this series led to the finding of (E)-1-(3-fluoro-6,11-dihydrodibenz[b,e]oxepin-11-yl)-4-(3-phenyl-2-prop enyl)piperazine dimaleate (50), AJ-3941 with the most appropriate property for combined pharmacological activities. Compound 50 also shows an inhibitory effect against cerebral edema as well when orally given to rats.
View MoreA.M FOOD CHEMICAL CO., LIMITED
Contact:86-531-87100375
Address:20Floor，Bblock，1Building，pharma-valley，Jinan，China
Shantou Baokang Pharmaceutical Co., Ltd.
Contact:+86-754-88873487
Address:5/F B Block Huangshan Bldg Huangshan Rd Shantou
Contact:Tel:+86-29-88764861 Fax:+86-29-88764861
Address:Rm#2107, Block A, Epin Meidao Building, Gaoxin Rd, Hi-Tech Zone, Xi’an, China
Hangzhou Gangjin Chemical Co.,Ltd.(expird)
Contact:+86-571-85109780
Address:707 Zhejiang Minhang Bldg., No.290 Zhongshan North Road, Hangzhou 310003, China
Contact:+91 9963263336
Address:Plot#146A, IDA Mallapur, Hyderabad - 500072
Doi:10.1016/j.tet.2017.06.034
(2017)Doi:10.1021/jo00406a026
(1978)Doi:10.1055/s-1978-24663
(1978)Doi:10.1016/j.molstruc.2003.09.016
(2004)Doi:10.1002/hlca.19780610128
(1978)Doi:10.1002/jlcr.2580130407
(1977)
