Chemical and Pharmaceutical Bulletin p. 2888 - 2895 (1991)
Update date:2022-08-03
Topics: Synthesis Derivatives Biological activities 1,4-Benzothiazine
Kajino
Mizuno
Tawada
Shibouta
Nishikawa
Meguro
New 2H-1,4-benzothiazin-3(4H)-one derivatives possessing (4-phenyl-1-piperazinyl)alkyl moieties at the 2-position were synthesized and tested for calcium antagonistic and calmodulin antagonistic activities. Antihypertensive effects in spontaneously hypertensive rats were also evaluated. In general, these compounds were rather weak calcium channel blockers, although, in contrast, many of them had moderate to potent calmodulin antagonistic activity, and 2-[3-(4-(4-fluorophenyl)-1-piperazinyl]propyl]-2H-1,4-benzothiazin-3(4H )-one derivatives 45, 74 and 75 showed potent antihypertensive effects.
View Morewebsite:http://www.truewingroup.com
Contact:86-311-66699812
Address:NO.600 ZHONGSHAN EAST ROAD SHIJIAZHUANG
ClickChem Technology Co., Limited
Contact:+86-0310-6519966/0531-52893837
Address:No.750 Shunhua Road, High-Tech Zone, Jinan city, Shandong China
shijiazhuang shuanglian chemical industry co.,ltd
Contact:0311-82190302
Address:Luquan Intersection , Shijiazhuang--Taiyuan Expressway，Shijiazhuang City
Lanling Hongchuang Flame Retardant Co., Ltd.
Contact:+86-531-68858132
Address:East Huafeichang Road, Cangshan County, Linyi, Shandong, China (Mainland)
Contact:+1-284-4950244
Address:Box 3069, Road Town, Tortola, British Virgin Islands
Doi:10.1002/ejoc.201403560
(2015)Doi:10.1002/ejoc.201101624
(2012)Doi:10.3987/COM-11-12396
(2012)Doi:10.1039/c2ob06964d
(2012)Doi:10.1080/00397911.2010.528572
(2012)Doi:10.1080/00958972.2012.675431
(2012)
