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Synthesis and biological activities of new 1,4-benzothiazine derivatives

DOI: 10.1248/cpb.39.2888

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 2888 - 2895 (1991)

Update date:2022-08-03

Topics: Synthesis   Derivatives   Biological activities   1,4-Benzothiazine  

Authors:

KajinoKajino

MizunoMizuno

TawadaTawada

ShiboutaShibouta

NishikawaNishikawa

MeguroMeguro

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Article abstract of DOI:10.1248/cpb.39.2888

New 2H-1,4-benzothiazin-3(4H)-one derivatives possessing (4-phenyl-1-piperazinyl)alkyl moieties at the 2-position were synthesized and tested for calcium antagonistic and calmodulin antagonistic activities. Antihypertensive effects in spontaneously hypertensive rats were also evaluated. In general, these compounds were rather weak calcium channel blockers, although, in contrast, many of them had moderate to potent calmodulin antagonistic activity, and 2-[3-(4-(4-fluorophenyl)-1-piperazinyl]propyl]-2H-1,4-benzothiazin-3(4H )-one derivatives 45, 74 and 75 showed potent antihypertensive effects.

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Full text of DOI:10.1248/cpb.39.2888

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Products guided by the article

Product name:2H-1,4-Benzothiazin-3(4H)-one, 2-(3-bromopropyl)-7-chloro-

Cas No:139331-33-2

139331-33-2

R&D Labs maybe for 139331-33-2

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