Synthesis of 6-Phosphonoalkyl Tetrahydro-4-pyrimidinecarboxylic Acids as NMDA Receptor Antagonists

Article abstract of DOI:10.1016/0040-4039(91)80558-N

The title compounds were prepared via a sequence which involved as the key steps a Michael reaction between nitroalkyl phosphonates and protected dehydroalanine and subsequent cyclization of the α,γ-diamino esters.Key Words: 6-phosphonoalkyl tetrahydro-4-