The Design and Synthesis of Cyclic Renin Inhibitors

DOI: 10.1016/0040-4039(91)80557-M

Source and publish data:

Tetrahedron Letters p. 7655 - 7658 (1991)

Update date:2022-08-02

Topics:

Authors:

Wittenberger, Steven J.

Baker, William R.

Donner, B. Gregory

Hutchins, Charles W.

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Article abstract of DOI:10.1016/0040-4039(91)80557-M

A prototype cyclic renin inhibitor was designed through a combined effort between Discovery and Computer Aided Molecular Design.Synthesis of the prototype structure provided compounds which showed weak inhibitory activity of the enzyme renin.

Full text of DOI:10.1016/0040-4039(91)80557-M

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