Tetrahedron Letters p. 7655 - 7658 (1991)
Update date:2022-08-02
Topics:
Wittenberger, Steven J.
Baker, William R.
Donner, B. Gregory
Hutchins, Charles W.
A prototype cyclic renin inhibitor was designed through a combined effort between Discovery and Computer Aided Molecular Design.Synthesis of the prototype structure provided compounds which showed weak inhibitory activity of the enzyme renin.
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