A convenient synthesis of a simple coumarin

DOI: 10.1248/cpb.39.3100

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 3100 - 3102 (1991)

Update date:2022-07-29

Topics:

Authors:

Ishii Ishii

Kaneko Kaneko

Miyazaki

Harayama

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Article abstract of DOI:10.1248/cpb.39.3100

Reaction of salicylaldehydes (1) with carbethoxymethylenephosphorane in diethylaniline under reflux gave coumarins (3) in excellent yields. Methoxy substituent at C'4 on salicylaldehyde (1) facilitated the formation of coumarin from trans-cinnamate (2), which is first prepared by reaction of 1 with Wittig reagent.

Full text of DOI:10.1248/cpb.39.3100

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