SYNTHESIS OF α,β-DISUBSTITUTED ALDEHYDES INVOLVING METALLATED 1-AZA-1,3-BUTADIENES IN THE PRESENCE OF PHOSPHINE COMPLEXES OF PALLADIUM

Article abstract of DOI:10.1007/BF00963504

A novel catalytic method was developed for the synthesis of α,β-disubstituted aldehydes by the reaction of N-, O-, and S-containing allyl electrophiles with magnesium azaenolates obtained by metallation of α,β-unsaturated imines by Grignard reagents.The reaction is carried out with high regio- and stereoselectivity in the presence of phosphine complexes of palladium.