Synthesis, benzodiazepine receptor binding and molecular modelling of isochromeno[4,3-c]pyrazol-5(1H)-one derivatives

Article abstract of DOI:10.1016/j.ejmech.2012.06.028

A series of isochromeno[4,3-c]pyrazole-5(1H)-one derivatives 7b-h were prepared and tested at 10 μM for their ability to displace specific [ ³H]flunitrazepam from bovine brain membranes. The substitution pattern of the above derivatives was sho