SOLID PHASE SYNTHESIS OF NEUTRAL OLIGONUCLEOTIDE ANALOGUES

Article abstract of DOI:10.1016/0040-4039(91)80113-K

The combination of an anchor for solid phase synthesis which allows release of fully protected oligonucleotide analogues from the solid support and base protective groups which provide water solubility has been shown to facilitate isolation, purification, and characterization of neutral oligonucleotide analogues derived from morpholine nucleosides.