Medicinal Chemistry Research p. 2023 - 2037 (2013)
Update date:2022-08-05
Topics:
Sahu, Krishnendu B.
Banerjee, Maitreyee
Ghosh, Soma
Maity, Arindam
Mondal, Shymal
Paira, Rupankar
Hazra, Abhijit
Karmakar, Sanmoy
Samanta, Amalesh
Mondal, Nirup B.
Friedel-Crafts reaction of differently substituted anilines with ninhydrin in the presence of molecular iodine at ambient temperature constitutes a facile, cost effective, and regioselective synthesis of a series of 2-mono/2,2-bis-(amino-phenyl)-indane-1,3-dione derivatives. Under identical conditions, use of different substituents in aniline ring led to the formation of different products, emphasizing the pivotal role of the nature and position of the substituents in product formation. In vitro antimicrobial activity evaluation of the synthesized molecules against eight bacterial and four fungal strains revealed that four of them possess duel efficacies (bactericidal as well as fungicidal). The activities are attributed to the disruption of architecture of the microbes as revealed from ultrastructural studies (SEM). Graphical Abstract: [Figure not available: see fulltext.]
View MoreShenzhen Hongyuan Import & Export Co., Ltd.
Contact:0755-26407171
Address:Shenzhen Hongyuan Chemical New Materials Technology Co., Ltd.
HAINAN JINYING IMPORT AND EXPORT CO. LTD
Contact:+86-898-32875423
Address:A SECTION 19TH FL, TIMES SQUARE, NO.2 GUO MAO AVENUE HAIKOU, HAINAN, P. R. OF CHINA
Contact:+8613400661290
Address:No 908,Kangwan Rd, Liuyang Economic
Shenzhen HwaGen Pharmaceutical Co., Ltd
website:http://www.rafflespt.com
Contact:+86-752-5538396
Address:Guangdong Huizhou China
Yuan Shi(SuQian)Biotechnology Co.,Ltd
website:http://www.yuanshibio.com
Contact:+86-527-84226672
Address:jiangsu suqian
Doi:10.1021/ic301454y
(2012)Doi:10.1016/j.tet.2012.07.070
(2012)Doi:10.1039/c2cc35080g
(2012)Doi:10.1080/00397911.2011.589561
(2013)Doi:10.1021/ol3023177
(2012)Doi:10.1002/anie.201203092
(2012)