3-(2-Carboxyindol-3-yl)propionic Acid-Based Antagonists of the N-Methyl-D-aspartic Acid Receptor Associated Glycine Binding Site

DOI: 10.1021/jm00088a014

Source and publish data:

Journal of Medicinal Chemistry p. 1791 - 1799 (1992)

Update date:2022-08-02

Topics: Antagonists

Authors:

Salituro, Francesco G.

Harrison, Boyd L.

Baron, Bruce M.

Nyce, Philip L.

Stewart, Kenneth T.

et al. et al.

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Article abstract of DOI:10.1021/jm00088a014

A series of substituted 3-(2-carboxyindol-3-yl)propionic acids was synthesized and tested as antagonists for the strychnine-insensitive glycine binding site of the NMDA receptor.Chlorine, and other small electron-withdrawing substituents in the 4- and 6-p

Full text of DOI:10.1021/jm00088a014

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