Benzoquinazoline Inhibitors of Thymidylate Synthase: Enzyme Inhibitory Activity and Cytotoxicity of Some Sulfonamidobenzoylglutamate and Related Derivatives

DOI: 10.1021/jm00074a030

Source and publish data:

Journal of Medicinal Chemistry p. 3464 - 3471 (1993)

Update date:2022-08-04

Topics:

Authors:

Pendergast, William

Dickerson, Scott H.

Johnson, Jay V.

Dev, Inderjit K.

Ferone, Robert

et al. et al.

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Article abstract of DOI:10.1021/jm00074a030

Several folate-like thymidylate synthase inhibitors are described in which the pteridine nucleus of the folic acid molecule is replaced by a benzoquinazoline moiety, which in turn is attached to the benzoylglutamate side chain by a sulfonamide link.The mo

Full text of DOI:10.1021/jm00074a030

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