Nitrile Oxides in Medicinal Chemistry. 4. Chemoenzymatic Synthesis of Chiral Heterocyclic Derivatives

DOI: 10.1021/jo00036a013

Source and publish data:

Journal of Organic Chemistry p. 2825 - 2829 (1992)

Update date:2022-07-29

Topics:

Authors:

Amici, Marco De

Magri, Paolo

Micheli, Carlo De

Cateni, Francesca

Bovara, Roberto

et al. et al.

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Article abstract of DOI:10.1021/jo00036a013

The two enantiomers of 3-bromo-5-(hydroxymethyl)-Δ²-isoxazoline (1) and 2-phenyl-5-(hydroxymethyl)-isoxazolidin-3-one (9) have been prepared in enantiomeric excess higher than 90percent by hydrolysis of the corresponding butyrates under the cat

Full text of DOI:10.1021/jo00036a013

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