Reversible protection of lysine to facilitate the purification of protected peptide segments

DOI: 10.1016/S0040-4039(00)74141-4

Source and publish data:

Tetrahedron Letters p. 397 - 400 (1992)

Update date:2022-08-05

Topics:

Authors:

Rizo, Josep

Albericio, Fernando

Giralt, Ernest

Pedroso, Enrique

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(00)74141-4

The polarity of temporarily free lysine side chains can be exploited to aid in the purification of protected peptides. The amine groups can easily be reprotected after the purification step. Impurities in commercial TFE¹ can cause trifluoroacetylation of free primary amines.

Full text of DOI:10.1016/S0040-4039(00)74141-4

Products guided by the article

Product name:Boc-Val-Ala-Leu-Leu-Lys(Tfa)-Ala-Leu-Tyr(Dcd)-Gly-OH

Cas No:140201-19-0

R&D Labs maybe for 140201-19-0

TIANJIN DONGRUXIANG MINERALS MARKETING CO.,LTD(expird)

Contact:22-58516360

Address:tianjin
Shanghai Apeptide Co., Ltd.

website:http://www.apeptides.com/en/

Contact:+86-21-60871011

Address:No. 80 Chuanshan Shuyuan Steet,Pudong,Shanghai
Nanjing Chemzam Pharmtech Co., Ltd.

Contact:+86-25-86462165,+86-13915979898

Address:C5-1，6 Maiyue Road，Maigaoqiao，Nanjing，Jiangsu，China
Buffett (China) Holding Co.,Ltd

Contact:4006570891

Address:
LIDE PHARMACEUTICALS LIMITED

website:http://www.lidepharma.com

Contact:+86-25-58409506

Address:11F, Building A1, No.288 North Zhongshan Road, Gulou District, Nanjing,210003, P.R.China.

Relevant to this article

Formation of 1,2,3,4-Tetrahydro-2-pyridones by Aza-Annulation of Imines with Acrylate Derivatives

Doi:10.1021/jo00046a011
(1992)
Acyl-protected hydroxylamines as spin label generators for EPR brain imaging

Doi:10.1021/jm0105169
(2002)
Total Synthesis of Ionomycin Using Ring-Opening Strategies

Doi:10.1021/ol025872f
(2002)
Synthesis of the BCD-ring of ciguatoxin 1B using an acetylene cobalt complex and vinylsilane strategy

Doi:10.1016/S0040-4020(02)00044-3
(2002)
Synthesis, structures, and UV-visible absorption spectra of tri(9 anthryl)bismuthine derivatives

Doi:10.1021/om020124f
(2002)
Green-emitting iridium(iii) complexes containing pyridine sulfonic acid as ancillary ligands for efficient OLEDs with extremely low efficiency roll-off

Doi:10.1039/c9tc03937f
(2019)

Article Doi