Reversible protection of lysine to facilitate the purification of protected peptide segments

DOI: 10.1016/S0040-4039(00)74141-4

Source and publish data:

Tetrahedron Letters p. 397 - 400 (1992)

Update date:2022-08-05

Topics:

Authors:

Rizo, Josep

Albericio, Fernando

Giralt, Ernest

Pedroso, Enrique

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Article abstract of DOI:10.1016/S0040-4039(00)74141-4

The polarity of temporarily free lysine side chains can be exploited to aid in the purification of protected peptides. The amine groups can easily be reprotected after the purification step. Impurities in commercial TFE¹ can cause trifluoroacetylation of free primary amines.

Full text of DOI:10.1016/S0040-4039(00)74141-4

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