Synthesis and biological activities of lipid A analogs: Modification of a glycosidically bound group with chemically stable polar acidic groups and lipophilic groups on the disaccharide backbone with tetradecanoyl or N-dodecanoylglycyl groups

Article abstract of DOI:10.1248/cpb.39.3244

Six novel lipid A analogs were synthesized. The first two analogs, 4 and 5, have an α-glycosidically bound carboxymethyl or 1,3-dicarboxyisopropyl group on the disaccharide backbone with four tetradecanoyl groups. The next three analogs, 6, 7 and 8, have