Synthesis and biological activities of lipid A analogs: Modification of a glycosidically bound group with chemically stable polar acidic groups and lipophilic groups on the disaccharide backbone with tetradecanoyl or N-dodecanoylglycyl groups

DOI: 10.1248/cpb.39.3244

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 3244 - 3253 (1991)

Update date:2022-07-30

Topics:

Authors:

Kusama Kusama

Soga Soga

Ono Ono

Kumazawa

Shioya Shioya

Nakayama

Uoto Uoto

Osada Osada

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.39.3244

Six novel lipid A analogs were synthesized. The first two analogs, 4 and 5, have an α-glycosidically bound carboxymethyl or 1,3-dicarboxyisopropyl group on the disaccharide backbone with four tetradecanoyl groups. The next three analogs, 6, 7 and 8, have

Full text of DOI:10.1248/cpb.39.3244

NII-Electronic Library Service

Products guided by the article

Product name:2-(diphenylphosphonooxy)ethyl 2-deoxy-6-O-<2-deoxy-4-O-diphenylphosphono-3-O-tetradecanoyl-6-O-(2,2,2-trichloroethoxycarbonyl)-2-(2,2,2-trichloroethoxycarbonylamino)-β-D-glucopyranosyl>-3-O-tetradecanoyl-2-(N-dodecanoylglycylamino)-α-D-glucopyranoside

Cas No:140236-19-7

R&D Labs maybe for 140236-19-7

SHANDONG ZHANHUA YONGHAO PHARMACEUTICAL TECH.CO.,LTD

Contact:+86-576-88685096

Address:GENGJU VILLAGE NORTH ONE KILOMETER,ZHANHUA DISTRICT,BINZHOU CITY,SHANDONG PROVINCE,CHINA.
Yangzhou Zhongbao Pharmaceutical Co.,Ltd

Contact:+86-514-88290838

Address:Jiangsu Baoying county economic develpment zone in baoying avenue91
Amadis Chemical Co., Ltd.

website:http://www.amadischem.com

Contact:86-571-89925085

Address:Watts Cosine.No.166.Xiangmao Road.
XI'AN CHUKANG BIOTECHNOLOGY CO.,LTD

Contact:29-63685658 63685359

Address:Room 3-1202,Building 1,Oriental oasis,East of Xianning Road,Xi'an,Shaanxi 710043 P.R.China
Dalian Synco Chemical Co., Ltd.

Contact:+86-411-83635150

Address:Rm 1004, 24, Tangshan Street, Dalian

Relevant to this article

Practical Synthesis of Cap-4 RNA

Doi:10.1002/cbic.201900590
(2020)
Anion directed synthesis of a hydrogensulfate selective luminescent rotaxane

Doi:10.1039/b418878k
(2005)
One-pot synthesis and the X-ray structures of rhenium(I) diphosphine hydrides, fac-(CO)₃(P-P)ReH [P-P = dppp, dppb, and dppfe]

Doi:10.1016/j.inoche.2004.10.020
(2005)
Double Michael addition reactions to tetrakis sulfonyl activated olefins

Doi:10.1002/jhet.5570420212
(2005)
Synthesis and Antiarrhythmic and Parasympatholytic Properties of Substituted Phenols. 1. Heteroarylamine Derivatives

Doi:10.1021/jm00360a005
(1983)
Catechol-bisphosphonate conjugates: New types of chelators for metal intoxication therapy

Doi:10.1002/hc.20056
(2004)

Article Doi