Angewandte Chemie - International Edition p. 6912 - 6915 (2012)
Update date:2022-08-04
Topics:
Bellomo, Ana
Celebi-Olcum, Nihan
Bu, Xiaodong
Rivera, Nelo
Ruck, Rebecca T.
Welch, Christopher J.
Houk, Kendall N.
Dreher, Spencer D.
A microscale chemistry improvement engine: A pre-dosed microscale high-throughput experimentation additives platform enables rapid, serendipitous reaction improvement. This platform allowed one chemist to set up 475 experiments and analyze the results using MISER chromatography in a single day, thus resulting in two high-quality catalytic systems for the construction of the title compound 1. Support for a single-electron transfer mechanism was obtained. Copyright
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