One-pot synthesis of 1-(trifluoromethyl)-4-fluoro-1,2-dihydroisoquinolines and 4,4-difluoro-1,2,3,4-tetrahydroisoquinolines

DOI: 10.1021/ol403059z

Source and publish data:

Organic Letters p. 6210 - 6213 (2013)

Update date:2022-07-29

Topics:

Authors:

Liu, Qilun

Wu, Yichen

Chen, Pinhong

Liu, Guosheng

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Article abstract of DOI:10.1021/ol403059z

A cascade approach to 1-(trifluoromethyl)-4-fluoro-1,2-dihydroisoquinolines and 4,4-difluorotetrahydroisoquinolines has been developed. The procedure involves a silver-catalyzed intramolecular aminofluorination of alkyne. This one-pot reaction provides an

Full text of DOI:10.1021/ol403059z

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