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the prepared magnetic solid was separated by a magnet and
washed with ethanol several times. The attained solid was
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¨
core–shell magnetic mesoporous N-doped silica nanoparticles
were synthesized and labeled as N(x wt%)-MSN (x ¼ the content
of nitrogen in the core–shell magnetic mesoporous N-doped
silica nanoparticles, as measured by the elemental analysis:
0.6, 1.3 and 1.7 wt%).
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To prepare the magnetic mesoporous silica nanoparticles (or,
namely, MSN), all the procedures were followed as per the
above-described method. However, the difference was that DEA
was not used. The synthesized solid was named as MSN.
Catalyst performance for the synthesis of arylpyrimido[4,5-b]
quinoline derivatives
For preparing the arylpyrimidoquinoline derivatives, 1 mmol of
aniline derivatives, 1 mmol of barbituric acid and 1 mmol of
benzaldehyde in the presence of 20 mg of the synthesized
catalyst in water and ethanol solvents (at a volumetric ratio 1 : 1
at 80 ꢀC) were reacted. The reaction progress was monitored by
TLC, and aer the completion of the reaction, the magnetic
catalyst was removed from the reaction medium by a magnet.
Furthermore, the obtained precipitate was ltered and washed
with cold ethanol and water and the structure of the product
was fully conrmed with FTIR, 1H NMR and 13C NMR data.24,36,37
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Conclusion
In this study, mesoporous magnetic N-doped silica nano-
particles as a heterogeneous basic catalyst (N(x wt%)-MSN) was
prepared. In the presented process, DEA was used as a nitrogen
source and TEOS as a silica precursor. The as-prepared catalyst
was applied successfully for the synthesis of some arylpyrimido
[4,5-b]quinoline-dione derivatives in high yields. The nitrogen
doping by this method is a new route for developing highly
efficient solid base catalysts.
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Conflicts of interest
There are no conicts to declare.
Acknowledgements
The Research Council of Kashan University should be appreci-
ated for supporting this work.
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