Reversible Inhibitors of the Gastric (H+/K+)-ATPase. 2. 1-Arylpyrroloquinolines: Effect of the 4-Substituent

Article abstract of DOI:10.1021/jm00088a021

Further work on compounds 1 has identified the 4-position as a site where substantial modifications are tolerated, leading to analogues which are more potent and less toxic than those described previously.The best compound in the series is 13a (SKandF 963