Journal of Medicinal Chemistry p. 1845 - 1852 (1992)
Update date:2022-08-03
Topics:
Leach, Colin A.
Brown, Thomas H.
Ife, Robert J.
Keeling, David J.
Laing, Shiona M.
et al.
Further work on compounds 1 has identified the 4-position as a site where substantial modifications are tolerated, leading to analogues which are more potent and less toxic than those described previously.The best compound in the series is 13a (SKandF 963
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