Reversible Inhibitors of the Gastric (H+/K+)-ATPase. 2. 1-Arylpyrroloquinolines: Effect of the 4-Substituent

DOI: 10.1021/jm00088a021

Source and publish data:

Journal of Medicinal Chemistry p. 1845 - 1852 (1992)

Update date:2022-08-03

Topics:

Authors:

Leach, Colin A.

Brown, Thomas H.

Ife, Robert J.

Keeling, David J.

Laing, Shiona M.

et al. et al.

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Article abstract of DOI:10.1021/jm00088a021

Further work on compounds 1 has identified the 4-position as a site where substantial modifications are tolerated, leading to analogues which are more potent and less toxic than those described previously.The best compound in the series is 13a (SKandF 963

Full text of DOI:10.1021/jm00088a021

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