Chemistry of O-silylated ketene acetals: A stereoselective synthesis of optically active carbapenem antibiotics, (+)-thienamycin and (+)-PS-5

DOI: 10.1248/cpb.40.12

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 12 - 20 (1992)

Update date:2022-08-03

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Authors:

Kita Kita

Shibata Shibata

Miki Miki

Takemura

Tamura Tamura

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Article abstract of DOI:10.1248/cpb.40.12

A stereoselective synthesis of the chiral thienamycin intermediate (16) involving a diastereoselective Michael addition and a silicon-induced Pummerer-type reaction is described. In a similar way, the key intermediate for (+)-PS-5 was also prepared from 4

Full text of DOI:10.1248/cpb.40.12

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