Directed ortho Lithiation in the Reactions of 3,5-Dimethyl- and 5-Trifluoromethyl-1-phenylpyrazoles with Butyllithium

DOI: 10.1246/cl.1992.357

Source and publish data:

Chemistry Letters p. 357 - 360 (1992)

Update date:2022-08-04

Topics:

Authors:

Iwata, Satoru

Qian, Cheng-Ping

Tanaka, Kiyoshi

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1246/cl.1992.357

Lithiation of 3,5-dimethyl- and 5-trifluoromethyl-1-phenylpyrazoles with butyllithium is found to be directed to an ortho position.The ortho direction is ascribed to coordination of lithium with pyrazole 2-nitrogen or 5-trifluoromethyl group, respectively.

Full text of DOI:10.1246/cl.1992.357

Products guided by the article

Product name:1H-Pyrazole, 3,5-dimethyl-1-[2-(trimethylsilyl)phenyl]-

Cas No:140647-22-9

R&D Labs maybe for 140647-22-9

Baoding City Light Industry And Textiles Imp.& Exp. Corp. Chemical Department.

Contact:86-312-3262436

Address:NO.658 CHAOYANG SOUTH STREET,BAODING CITY HEBEI CHINA
Shenzhen Feiming Science and Technology Co,. Ltd

Contact:+86-755-85232577

Address:#B2309, Fenglin International Center ,Jixiang Road, Longcheng street, LongGang District, Shenzhen city, Guangdong province, China.
Ningbo Huajia Chemicals

Contact:+86-574-87065746

Address:10th Floor, No.787 Baizhang East Road,
Shanghai He Yang International Trading Co., Ltd.

Contact:+86-21-52043598

Address:Room 816, Blag.5, No.58 Huachi Road
Anhui New Star Pharmaceutical Development Co., Ltd

Contact:013956922763

Address:Floor 3, F9A, F Workshop, No.110 Kexue Road, High-Tech Development Zone, Hefei, Anhui ,China

Relevant to this article

Aryllithiums with increasing steric crowding and lipophilicity prepared from chlorides in diethyl ether. the first directly prepared room-temperature-stable dilithioarenes

Doi:10.1021/ol302672n
(2012)
A new imidazophenanthroline derivative and its Hg(II) complex: Structures, photophysical properties, and DFT calculations

Doi:10.1080/00958972.2012.729822
(2012)
Fine-Tunable 3,4-dihydroquinazol-2-ylidene carbenes: Synthesis, rhodium(I) complexes, and reactivity

Doi:10.1021/om300887y
(2012)
Identification of small-molecule enhancers of arginine methylation catalyzed by coactivator-associated arginine methyltransferase 1

Doi:10.1021/jm301097p
(2012)
Copper promoted Chan-Lam type O-arylation of oximes with arylboronic acids at room temperature

Doi:org/10.1016/j.tetlet.2012.09.003
(2012)
First synthetic analogues of diphosphoinositol polyphosphates: Interaction with PP-InsP₅ kinase

Doi:10.1039/c2cc36044f
(2012)

Article Doi