Fluorinated amino acids and peptides. Synthesis of 3,3-difluoro-2-amino acids, peptides and cyclodipeptides incorporating 3,3-difluoro-2-aminobutyric acid or 3,3-difluorophenylalanine residues in their structures

Article abstract of DOI:10.1016/S0022-1139(00)81249-X

Convenient syntheses have been developed for N-9-fluorenylmethyloxycarbonyl-DL-2-amino-3,3-difluoro-butanoic acid and N-9-fluorenylmethyloxycarbonyl-DL-3,3-difluoro-phenylalanine which have been successfully introduced into peptide syntheses.Several fluor