Avermectin-milbemycin synthetic studies. 6. Stereoselective elaboration of the 'southern hemisphere' oxahydrindene

Article abstract of DOI:10.1016/S0040-4039(00)91891-4

An economic, stereoselective synthesis of the highly oxygenated oxahydrindene nucleus of the avermectin-milbemycin family of anthelmintics has been achieved, exploiting a facile intramolecular S(N)2' cyclization as the key step.