Avermectin-milbemycin synthetic studies. 6. Stereoselective elaboration of the 'southern hemisphere' oxahydrindene

DOI: 10.1016/S0040-4039(00)91891-4

Source and publish data:

Tetrahedron Letters p. 1185 - 1188 (1992)

Update date:2022-09-26

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Authors:

Fujiwara

Smith III

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Article abstract of DOI:10.1016/S0040-4039(00)91891-4

An economic, stereoselective synthesis of the highly oxygenated oxahydrindene nucleus of the avermectin-milbemycin family of anthelmintics has been achieved, exploiting a facile intramolecular S(N)2' cyclization as the key step.

Full text of DOI:10.1016/S0040-4039(00)91891-4

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