Spacer-modified disaccharide and pseudo-trisaccharide methyl glycosides that mimic maltotriose, as competitive inhibitors for pancreatic alpha-amylase: A demonstration of the 'clustering effect'

Article abstract of DOI:10.1016/0008-6215(92)84093-8

The synthesis is reported of methyl 4,4'-dithio-α-maltotrioside (12) and the spacer-modified disaccharide glycosides methyl 4-S-(4-α-D-glucopyranosylthio-2-hydroxybutyl)-4-thio-α-D- glucopyranoside (20) and methyl 4-S-[1,5/4,6)- and (4,6/1,5)-4-α-D-glucop