Facile unmasking of ethenylated isocytosines via diacetoxylation with lead tetraacetate

DOI: 10.1248/cpb.40.235

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 235 - 237 (1992)

Update date:2022-08-04

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Authors:

Sako Sako

Totani Totani

Hirota Hirota

Maki Maki

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Article abstract of DOI:10.1248/cpb.40.235

Treatment of ethenylated isocytosines, imidazolo[1,2-a]pyrimidine-5(1H)-one (2) and -7(8H)-one (3), with lead tetraacetate (LTA) in glacial acetic acid followed by alkaline hydrolysis resulted in the smooth removal of the ethenyl group to give isocytosine (1) in high yields. The unmasking of 2 by LTA to 1 was compared with the results using iodosylbenzene diacetate and N-bromosuccinimide.

Full text of DOI:10.1248/cpb.40.235

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