Iodocyclization of o -alkynylbenzamides revisited: Formation of isobenzofuran-1(3 H)-imines and 1 H -isochromen-1-imines instead of lactams

DOI: 10.1021/jo3017378

Source and publish data:

Journal of Organic Chemistry p. 10118 - 10124 (2012)

Update date:2022-08-05

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Authors:

Schlemmer, Claudine

Andernach, Lars

Schollmeyer, Dieter

Straub, Bernd F.

Opatz, Till

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Article abstract of DOI:10.1021/jo3017378

The iodocyclization of o-alkynylbenzamides with various electrophiles has been reported to yield five- or six-membered lactams by nucleophilic attack of the amide nitrogen onto the triple bond. While the formation of an isobenzofuran-1(3H)-imine with two

Full text of DOI:10.1021/jo3017378

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