Utilization of O-xylylene N,N-diethylphosphoramidite for the synthesis of phosphoric diesters

Article abstract of DOI:10.1016/S0040-4039(00)91610-1

o-Xylylene alkyl phosphites which were derived by the reaction of alcohols with o-xylylene N,N-diethylphosphoramidite in the presence of 1H-tetrazole were reacted with second alcohols in the presence of pyridinium bromide perbromide, and a tert-amine, to give the corresponding triesters involving phospholipids. The esters were deprotected to phosphoric diesters by hydrogenolysis or the reaction with disodium disulfide.