Functionalization of vitamin D metabolites at C-18 and application to the synthesis of 1 α, 18,25-trihydroxyvitamin D3 and 18,25-dihydroxyvitamin D3

Article abstract of DOI:10.1016/S0040-4039(00)91659-9

A general procedure for the introduction of a hydroxyl group at C-18 in several intermediates derived from the Inhoffen-Lythgoe diol is described for the first time. As an application, the syntheses of 1α, 18,25-trihydroxyvitamin D₃ (2, dienyne