Synthesis and antipancreatitis activities of novel N-(2-sulfonylamino-5- trifluoromethyl-3-pyridyl)carboxamide derivatives as phospholipase A2 inhibitors

DOI: 10.1248/cpb.43.1696

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1696 - 1700 (1995)

Update date:2022-09-26

Topics: Synthesis Inhibitors Phospholipase A2

Authors:

Kimura Kimura

Yotsuya Yotsuya

Yuki Yuki

Sugi Sugi

Shigehara

Haga Haga

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Article abstract of DOI:10.1248/cpb.43.1696

Novel N-(2-sulfonylamino-5-trifluoromethyl-3-pyridyl)carboxamide derivatives have been prepared and evaluated as phospholipase A₂ (PLA₂) inhibitors. Among these compounds, IS-741 (sodium salt of 1j), which showed the highest and the most stable therapeutic effect on acute hemorrhagic pancreatitis induced by the closed duodenal loop method in rats, was selected as a candidate for further development.

Full text of DOI:10.1248/cpb.43.1696

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Product name:N-{2-[(methylsulfonyl)amino]-5-(trifluoromethyl)pyridin-3-yl}cyclohex-3-ene-1-carboxamide

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