The Use of Lewis Acids in Radical Chemistry. Chelation-Controlled Radical Reductions of Substituted α-Bromo-β-alkoxy Esters and Chelation-Controlled Radical Addition Reactions

Article abstract of DOI:10.1021/jo980636x

The radical reduction of a series of α-bromo-β-alkoxy esters under chelation-controlled conditions is reported. Proceeding with high stereoselectivity in the presence of MgBr₂middot;OEt₂, reductions give access to syn products. Syste