Renin inhibitors containing C-termini derived from mercaptoheterocycles

DOI: 10.1021/jm00089a023

Source and publish data:

Journal of Medicinal Chemistry p. 2103 - 2112 (1992)

Update date:2022-08-06

Topics:

Authors:

Ashton Ashton

Cantone Cantone

Meurer Meurer

Tolman Tolman

Greenlee

Patchett

Lynch Lynch

Schorn Schorn

Strouse Strouse

Siegl Siegl

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Article abstract of DOI:10.1021/jm00089a023

A series of transition-state analogues having heterocyclythio C-termini has been synthesized and evaluated for inhibition of human renin. Addition of mercaptoheterocycles to a chiral Boc-amino epoxide intermediate led, after several steps, to the target [

Full text of DOI:10.1021/jm00089a023

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