Organic and Biomolecular Chemistry p. 8953 - 8955 (2012)
Update date:2022-08-03
Topics:
Shi, Jingjing
Zhou, Bing
Yang, Yaxi
Li, Yuanchao
Direct C-2 amidation of indoles was reported using sulfonyl azides as the amino source to release N2 as the single byproduct. This reaction exhibits high functional group tolerance and regioselectivity, providing a variety of 2-amino substituted indoles in high to excellent yield. The procedure is robust, reliable, and compatible with water and air.
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