Electrophilic opioid ligands. Oxygen tethered α-methylene-γ-lactone, acrylate, isothiocyanate, and epoxide derivatives of 6β-naltrexol

Article abstract of DOI:10.1021/jm00091a005

O⁶-Ether derivatives of 6β-naltrexol in which the ether substituent includes various electrophilic groups have been synthesized in an effort to examine structure-activity requirements at the 6β-substituent for receptor affinity and irreversibil