An efficient one-pot synthesis of pyrrolo[4,3,2-ij]isoquinoline derivatives by a consecutive aza-wittig/electrocyclic ring-closure/intramolecular acylation process

Article abstract of DOI:10.1055/s-1992-26095

Iminophosphorane, ethyl 5-ethoxycarbonyl-2-methoxy-α-[(triphenylphosphoranylidene)amino]cinn amate (4) reacts with aliphatic and aromatic isocyanates in toluene at 170°C to give directly the corresponding pyrrolo[4,3,2-ij]isoquinolines 8 in moderate yields.