Highly cis-selective synthesis of iodo-aziridines using diiodomethyllithium and in situ generated N-Boc-imines

DOI: 10.1039/c2cc37029h

Source and publish data:

Chemical Communications p. 12246 - 12248 (2012)

Update date:2022-09-26

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Authors:

Bull, James A.

Boultwood, Tom

Taylor, Thomas A.

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Article abstract of DOI:10.1039/c2cc37029h

The first preparation of iodoaziridines is described. The addition of diiodomethyllithium to N-Boc-imines affords these novel aziridines in high yields. The reaction proceeds in one-pot via a highly diastereoselective cyclisation of an amino gem-diiodide

Full text of DOI:10.1039/c2cc37029h

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