ACS Medicinal Chemistry Letters p. 936 - 941 (2015)
Update date:2022-08-02
Topics:
Liu, Ping
Hu, Zhiyong
Dubois, Byron G.
Moyes, Christopher R.
Hunter, David N.
Zhu, Cheng
Kar, Nam Fung
Zhu, Yuping
Garfunkle, Joie
Kang, Ling
Chicchi, Gary
Ehrhardt, Anka
Woods, Andrea
Seo, Toru
Woods, Morgan
Van Heek, Margaret
Dingley, Karen H.
Pang, Jianmei
Salituro, Gino M.
Powell, Joyce
Terebetski, Jenna L.
Hornak, Viktor
Campeau, Louis-Charles
Lamberson, Joe
Ujjainwalla, Fez
Miller, Michael
Stamford, Andrew
Wood, Harold B.
Kowalski, Timothy
Nargund, Ravi P.
Edmondson, Scott D.
We report herein the design and synthesis of a series of potent and selective GPR119 agonists. Our objective was to develop a GPR119 agonist with properties that were suitable for fixed-dose combination with a DPP4 inhibitor. Starting from a phenoxy analo
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