Chemical mechanism of inactivation of bee venom phospholipase A2 by the marine natural products manoalide, luffariellolide, and scalaradial

DOI: 10.1021/ja00039a021

Source and publish data:

Journal of the American Chemical Society p. 5093 - 5100 (1992)

Update date:2022-09-26

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Authors:

Potts, Barbara C. M.

Faulkner, D. John

De Carvalho, Marianne S.

Jacobs, Robert S.

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Article abstract of DOI:10.1021/ja00039a021

Inhibition of bee venom phosphohpase A₂ (PLA₂) by manoalide (1) and luffariellolide (2) involves the initial formation of a Schiff base (imine) between a lysine residue on PLA₂ and an aldehyde group on each of the drugs. M

Full text of DOI:10.1021/ja00039a021

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