Nonpeptide angiotensin II receptor antagonists: Synthetic and computational chemistry of N-[[4-[2-(2H-tetrazol-5-yl)-1-cycloalken-1- yl]phenyl]methyl]imidazole derivatives and their in vitro activity

Article abstract of DOI:10.1021/jm00092a017

A series of nonpeptide angiotensin II receptor antagonists was synthesized and tested in vitro to investigate requirements for recognition by and binding to AT₁ receptors. Compared to a known series of N- (biphenylylmethyl)imidazoles, including