Synthesis p. 163 - 168 (1992)
Update date:2022-08-04
Topics:
Nagai
Gaudino
Wilcox
The data in this paper suggest that reactions of Grignard reagents with dialkylaminofuranosides derived from pentoses proceed via α-alkoxyiminium ions and that these α-alkoxyiminium ions react quite stereoselectively. The rate of this reaction is dependent on the substituent at the 5-position of the pentose. A 5-deoxy analog is shown to react very slowly compared with a 5-O-methoxymethyl derivative. Importantly, the face selectivity of iminium ions with nucleophiles is shown to be opposite that expected and observed for reactions of aldehydes. A predictive mechanistic model is presented.
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Doi:10.1021/ja00041a047
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