An efficient route to enantiomerically pure antidepressants: Tomoxetine, nisoxetine and fluoxetine

Article abstract of DOI:10.1016/S0957-4166(00)80257-8

Both enantiomers (R)- and (S)-3-chloro-1-phenyl-1-propanol can be obtained conveniently by an efficient enzymatic resolution process. They can be converted via enantioconvergent routes into all enantiomers of the important antidepressants (R)- and (S)-Tomoxetine, Fluoxetine and Nisoxetine.