ASYMMETRIC SYNTHESIS OF PYRROLIZIDINONES BY RADICAL CYCLIZATION OF N-ALLYLIC PYROGLUTAMATES

DOI: 10.1016/S0040-4039(00)99247-5

Source and publish data:

Tetrahedron Letters p. 3369 - 3372 (1989)

Update date:2022-08-03

Topics:

Authors:

Keusenkothen, Paul F.

Smith, Michael B.

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Article abstract of DOI:10.1016/S0040-4039(00)99247-5

Ethyl S-pyroglutamate is converted to N-allylic-S C₅-iodomethyl-2-pyrrolidinone.Facile radical cyclization on treatment with AIBN and tributyltin hydride in refluxing benzene gives good yields of the C₆ substituted pyrrolizidin-2-one

Full text of DOI:10.1016/S0040-4039(00)99247-5

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