ASYMMETRIC SYNTHESIS OF PYRROLIZIDINONES BY RADICAL CYCLIZATION OF N-ALLYLIC PYROGLUTAMATES

DOI: 10.1016/S0040-4039(00)99247-5

Source and publish data:

Tetrahedron Letters p. 3369 - 3372 (1989)

Update date:2022-08-03

Topics:

Authors:

Keusenkothen, Paul F.

Smith, Michael B.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(00)99247-5

Ethyl S-pyroglutamate is converted to N-allylic-S C₅-iodomethyl-2-pyrrolidinone.Facile radical cyclization on treatment with AIBN and tributyltin hydride in refluxing benzene gives good yields of the C₆ substituted pyrrolizidin-2-one

Full text of DOI:10.1016/S0040-4039(00)99247-5

Products guided by the article

Product name:(4aS,8aS,9aS)-Decahydro-pyrrolo[1,2-a]indol-3-one

Cas No:142130-12-9

R&D Labs maybe for 142130-12-9

Shanghai Mintchem Development ., Ltd

Contact:0086 21 5190 8570

Address:R602,4#,89Nong, Mudan Road Pudong Shanghai China
Xi'an Terra Biochem Co. Ltd.

Contact:0086-29-88315623

Address:S711, Innovation Bldg No.25 Gaoxin 1st Rd, Xian P.R of China 710075
Hubei Xinghuo Chemical Co., Ltd.,

Contact:13925817279 13907299441

Address:Xinghuo Fine Chemistry Industrial Park, Xiaochang County, Hubei Province, China
Tengzhou Runlong Fragrance Co., Ltd.

website:http://www.tzrunlong.com/

Contact:--

Address:No. 78, Fushan Road, Biomedical Industrial Park, Dawu Town, Tengzhou, Shandong, 277514 China
SYN Pharma Co., Ltd

Contact:86-21 60347964

Address:No.1304, West Meilong Road, Minhang District, Shanghai, China

Relevant to this article

Iron-catalyzed benzannulation reactions of 2-alkylbenzaldehydes and alkynes leading to naphthalene derivatives

Doi:10.1021/ol4000394
(2013)
Design and exploration of novel boronic acid inhibitors reveals important interactions with a clavulanic acid-resistant sulfhydryl-variable (SHV) β-lactamase

Doi:10.1021/jm301490d
(2013)
Intramolecular cyclization of N-propargylic β-enaminones catalyzed by silver

Doi:10.1016/j.tetlet.2012.11.086
(2013)
Spirotriazoline oxindoles: A novel chemical scaffold with in vitro anticancer properties

Doi:10.1016/j.ejmech.2017.09.037
(2017)
Synthesis of a sodium-hydrogen exchange type 1 inhibitor: An efficient Cu-catalyzed conjugated addition of a Grignard reagent to an acetyl pyridinium salt

Doi:10.1021/op300331b
(2013)
A nitrogen-ligated nickel-catalyst enables selective intermolecular cyclisation of β- And γ-amino alcohols with ketones: Access to five and six-membered N-heterocycles

Doi:10.1039/c8gc00318a
(2018)

Article Doi