Tetrahedron Letters p. 3369 - 3372 (1989)
Update date:2022-08-03
Topics:
Keusenkothen, Paul F.
Smith, Michael B.
Ethyl S-pyroglutamate is converted to N-allylic-S C5-iodomethyl-2-pyrrolidinone.Facile radical cyclization on treatment with AIBN and tributyltin hydride in refluxing benzene gives good yields of the C6 substituted pyrrolizidin-2-one
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