Bioorganic and Medicinal Chemistry Letters p. 912 - 916 (2013)
Update date:2022-07-30
Topics:
Bandgar, Babasaheb P.
Chavan, Hemant V.
Adsul, Laxman K.
Thakare, Vishnu N.
Shringare, Sadanand N.
Shaikh, Rafik
Gacche, Rajesh N.
A series of novel pyrazole integrated benzophenones (9a-j) have been designed, synthesized from 1-methyl-5-(2,4,6-trimethoxy-phenyl)-1H-pyrazole 6. The structures of the regioisomers 6 and 7 were determined by 2D 1H-1H COSY, 1H-13C HSQC and 1H-13C HMBC experiments. The newly synthesized compounds (9a-j) were evaluated for in vivo anti-inflammatory activity by carrageenan paw edema in rats and in vitro COX-1/COX-2 inhibition and antioxidant potential. Among the synthesized compounds, compounds 9b, 9d and 9f, were found to be active anti-inflammatory agents in addition to having potent antioxidant activity.
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Doi:10.1021/ja308784w
(2013)Doi:10.1039/d0cc07019j
(2021)Doi:10.1016/j.bmc.2012.12.006
(2013)Doi:10.1016/j.poly.2012.10.050
(2013)Doi:10.1021/jo302790y
(2013)Doi:10.1016/j.ejmech.2012.11.010
(2013)
