Novel 9-Alkyl- and 9-Alkylidene-Substituted 1α,25-Dihydroxyvitamin D3 Analogues: Synthesis and Biological Examinations

DOI: 10.1021/acs.jmedchem.5b00795

Source and publish data:

Journal of Medicinal Chemistry p. 6237 - 6247 (2015)

Update date:2022-08-04

Topics:

Authors:

Kulesza, Urszula

Plum, Lori A.

DeLuca, Hector F.

Mouri?o, Antonio

Sicinski, Rafal R.

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Article abstract of DOI:10.1021/acs.jmedchem.5b00795

Continuing the structure-activity relationship studies in the vitamin D area, we designed and synthesized novel C-9 substituted calcitriol analogues, possessing different nonpolar groups at this position. 9α-Methyl-1α,25-(OH)₂D₃, bot

Full text of DOI:10.1021/acs.jmedchem.5b00795

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