Diastereomeric resolution of racemic o-chloromandelic acid

DOI: 10.1002/chir.22089

Source and publish data:

Chirality p. 1013 - 1017 (2012)

Update date:2022-08-04

Topics:

Authors:

Wang, Pei

Zhang, En

Zhao, Peng

Ren, Qing-Hua

Guan, Yuan-Yuan

Liu, Hong-Min

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Article abstract of DOI:10.1002/chir.22089

The separation of rac-o-chloromandelic acid 1 with enantiopure aryloxypropylamine via diastereomeric salt formation was investigated. (R)-o-chloromandelic acid (R)-1, a key intermediate for the antithrombotic agent clopidogrel, was obtained in 65% yield a

Full text of DOI:10.1002/chir.22089

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