Syntheses of (-)-Tatarinoid A, (±)-Tatarinoid B, and (-)-Tatarinoid C

Article abstract of DOI:10.1016/j.tetlet.2012.10.104

The syntheses of (-)-Tatarinoid A, (±)-Tatarinoid B, and (-)-Tatarinoid C in one to three steps are described herein. (-)-Tatarinoid A and (-)-Tatarinoid C are both constructed in three steps from 1-bromo-2,4,5-trimethoxybenzene in overall yields of 63% and 74%, respectively. The addition of (1-methoxyethyl)triphenylphosphonium ylide to 2,4,5-trimethoxybenzaldehyde provides (±)-Tatarinoid B in one step in 97% yield.