Journal of Medicinal Chemistry p. 6315 - 6329 (2019)
Update date:2022-07-29
Topics:
Zheng, Xiufang
Gao, Lu
Wang, Lisha
Liang, Chungen
Wang, Baoxia
Liu, Yongfu
Feng, Song
Zhang, Bo
Zhou, Mingwei
Yu, Xin
Xiang, Kunlun
Chen, Li
Guo, Tao
Shen, Hong C.
Zou, Gang
Wu, Jim Zhen
Yun, Hongying
Ziresovir (RO-0529, AK0529) is reported here for the first time as a promising respiratory syncytial virus (RSV) fusion (F) protein inhibitor that currently is in phase 2 clinical trials. This article describes the process of RO-0529 as a potent, selective, and orally bioavailable RSV F protein inhibitor and highlights the in vitro and in vivo anti-RSV activities and pharmacokinetics in animal species. RO-0529 demonstrates single-digit nM EC50 potency against laboratory strains, as well as clinical isolates of RSV in cellular assays, and more than one log viral load reduction in BALB/c mouse model of RSV viral infection. RO-0529 was proven to be a specific RSV F protein inhibitor by identification of drug resistant mutations of D486N, D489V, and D489Y in RSV F protein and the inhibition of RSV F protein-induced cell-cell fusion in cellular assays.
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