A green protocol for one-pot three-component synthesis of α-amino phosphonates catalyzed by succinic acid

Article abstract of DOI:10.1007/s11164-013-1081-8

A simple, efficient, and general method has been developed for the one-pot, three-component synthesis of α-amino phosphonates from a condensation reaction of trialkyl phosphite, aldehydes, and amines in the presence of a catalytic amount of succinic acid (8.5 mol %) (for the first time) under solvent-free conditions. The advantages of this protocol are excellent yields, short reaction time, mild reaction conditions, higher availability, low costs, more environmentally friendly, lack of need for column chromatography and simple work-up procedure. Graphical Abstract: [Figure not available: see fulltext.]