Formation of oxazolines and thiazolines in peptides by the Mitsunobu reaction

Article abstract of DOI:10.1016/S0040-4039(00)78864-2

The Mitsunobu reaction was efficiently used to introduce oxazolines and thiazolines in the peptide backbone. The reaction proceeded from β-hydroxy α-amino acid-containing peptides at room temperature in 58-72% isolated yields.